P/Q-Calcium Channel Antibody (LEMS® Assay) - RIA
Radio Receptor Assay
for the quantitative determination of
autoantibodies against the
voltage-gated calcium-channel (VGCC) in serum. Purified calcium channels of P/Q-subtype, labelled with 125I-ω-Conotoxin MVIIC
1 positive and 1 negative control
2 x 25 µl diluted (1:10) patient serum
1. incubation: 1 hour at room temperature
2. incubation: 1 hour at room temperature
Neurology, Immunology, Autoimmune Diseases
Lambert-Eaton Syndrome; differential diagnosis of myasthenic syndromes
Healthy donors ≤30 pmol/L (n=160)
Samples from 160 individual healthy blood donors were assayed in the LEMs Assay RIA. 160 (100%) were identified as being negative for VGCC Ab.
Samples from 50 patients diagnosed with LEMS were assayed in the LEMs Assay RIA. 50 (100%) were identified as being positive for VGCC Ab.