Product Information

Aquaporin-4 (AQP4) Antibody - ELISA

Catalog-No.

EA111/96
Enzyme Immuno Assay
for the quantitative determination of
autoantibodies to aquaporin-4 (AQP4) in serum

Format

12x8 Determinations
microtiter plate

Procedure

Clinical Fields

Neurology, Immunology, Autoimmune Diseases

Diseases

Neuromyelitis Optica, also known as Devic´s syndrome

Normal Value

< 3 units/ml is negative; > 3 units/ml is positive

Specificity

99% for n = 358 healthy blood donors

Sensitivity

77% for n = 62 patients with NMO or NMO spectrum disorder

Characteristics

Reliable and convenient method to measure AQP4 autoantibodies, which are a specific marker for Neuromyelitis Optica (NMO), also known as Devic’s syndrome.

Measurement of AQP4 autoantibodies can be of considerable value in distinguishing NMO from Multiple Sclerosis when full clinical features may not be apparent and early intervention may prevent or delay disability. Total assay time is ~3 hours only. The ELISA method is an easy assay format for use in the routine clinical laboratory and suitable for automated systems.

The ELISA is manufactured under licence to US patent 7,101,679 and 7,947,254 and European patent 1700120 and related patents and patents pending in other countries.

Instruction Sheet