Product Information

VGKC Antibody Assay - RIA

Catalog-No.

RA115/25
Radio Immuno Assay
for the determination of
autoantibodies to Voltage-Gated Potassium Channels (VGKC) in serum

Format

25 Determinations
over night incubation

Procedure

Clinical Fields

Neurology, Immunology, Autoimmune Diseases

Diseases

Voltage-Gated Potassium Channelopathies and related neurological disorders such as aquired neuromyotonia, crampfasciculation syndrome, Morvan syndrome, epilepsy, encephalitis

Normal Value

< 85 pmoles/l is negative; > 85 pmole is positive

Specificity

100 %; n=55 healthy blood donors 

Sensitivity

Characteristics

Reliable and convenient method to measure specific VGKC Abs which are useful in the diagnosis and management of auto-immune Voltage-gated Potassium Channelopathies and related neurological disorders

Literature:

“Autoantibodies detected to expressed K+ channels are implicated in Neuromyotonia”
I.K. Hart et al.; Ann. Neurol. 1997 41: 238 - 246

“Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis”
A. Vincent et al., Brain 2004 127: 701 – 712

“Clinical spectrum of voltage-gated potassium channel autoimmunity”
K.M. Tan et al.; Neurology 2008 70: 1883 - 1890

Instruction Sheet