Product Information
Zinc Transporter 8 (ZnT8) Antibody - ELISA
EA102/96
Enzyme Immuno Assay
for the quantitative determination of autoantibodies to the
zinc transporter 8 (ZnT8) in serum
12x8 Determinations
micotiter strips, single break apart
25 microlitre calibrators, controls and samples into wells,
16-20 hrs. incubation, 3 x wash
add ZnT8-Biotin, 1h incubation
3 x wash, add SA-POD, 20 min incubation
3 x wash, add substrate, 20 min incubation
stop reaction + read
Internal medicine, immunology, endocrinology
see Instructions for Use
Negative < 15 U/ml; Positive ≥ 15 U/ml
99 % ; n = 90 for healthy blood donors (IASP-Study 2016)
72 %; n = 50 for type 1 DM patients (IASP-Study 2016)
Literature:
J. M. Wenzlau et al.
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type I diabetes.
PNAS 2007 104:17040-17045
P. Achenbach et al.
Autoantibodies to zinc transporter 8 and SLc30A8 genotype stratify type 1 diabetes risk.
Diabetologia 2009 52:1881-1888
J. M. Wenzlau et al .
Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects.
J Clin Endocrinol Metab 2010 95:4712 - 4719
L. Petruzelkova et al
The dynamic changes of zinc transporter 8 autoantibodies in Czech children for the onset of type 1 diabetes mellitus.
Diabet Med 2014 31:165 - 71
G. Dunseath et al
Bridging-type enzyme-linked immunoassay for zinc transporter 8 autoantibody measurements in adult patients with diabetes mellitus.
Clin. Chim. Acta. 2015 447:90 - 95