Product Information

LEMS® N-type Assay - RIA

Catalog-No.

RA121/25
Radio Receptor Assay for the quantitative determination of autoantibodies against the voltage-gated calcium-channel (VGCC) in serum or plasma. Purified calcium channels of N-subtype, labelled with 125I-
ω-Conotoxin GVIA

Format

25 Determinations
2 positive and 1 negative control

Procedure

2 x 5 µl serum or plasma
1. incubation: over night at 2-8°C
2. incubation: 1.5 hours at 2-8°C

Clinical Fields

Neurology, Immunology, Autoimmune Diseases

Diseases

Lambert-Eaton myasthenic Syndrome; disorders of the CNS, incl. cerebellar degeneration and paraneoplastic syndromes in Small Cell Lunger Cancer (SCLC)

Normal Value

≤ 110 pmol/l

Specificity

98.3%; n = 59 individual healthy blood donors

Sensitivity

30%; n = 20 patients positive for P/Q-type VGCC Ab

Instruction Sheet