Canine ACHRAB® - RIA
Radio Receptor Assay for the Determination of
Autoantibodies against the Acetylcholin Receptor
Sample: 5 µl dog serum
Incubation: 2x 2 hours at room temperature
Neurology, Immunology, Autoimmune Diseases of dogs
Myasthenia gravis of dogs
Negative < 1,0 nmol/lPositive ≥ 1,0 nmol/l
Sera of 24 healthy dogs were tested in Canine ACHRAB® RIA.
23 (96%) were identified as negative for Canine AChR autoantibodies.
Sera of 4 dogs diagnosed with myasthenia gravis were tested in the
Canine ACHRAB® RIA. All 4 were identified as positive for Canine AChR
A published study showed: "At a cut-off of 1.3 nmol/l, the Canine ACHRAB® RIA showed a sensitivity of 100%, a specificity of 98.20%, a PPV of 80.00% and a NPV of 100%. When only dogs with neuromuscular disease and megaesophagus were considered, the results were as follows: Sensitivity 100%, Specificity 97.50%, PPV 94.12%, NPV 100%. When compared with the reference method, the new RIA showed mostly higher readings and appeared more sensitive in individual patients." Translated orig. citation from: Tierarztl Prax Ausg K Kleintiere Heimtiere 2023; 51: 55–62, DOI 10.1055/s-0043-1760812